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Diazepam (Valium) and other benzodiazepines bind to specific GABA receptors in the central nervous system,and inhibit neuronal activity by _____ the conductance of ______ ions into the neuron.


A) increasing;sodium
B) decreasing;sodium
C) increasing;potassium
D) decreasing;potassium
E) increasing;chloride

F) A) and C)
G) B) and D)

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E

When used to treat anxiety disorders,buspirone (BuSpar) acts by increasing the effects of _________ in certain areas of the brain,whereas traditional antianxiety drugs,such as diazepam (Valium) ,increase the inhibitory effects of _______ in the central nervous system.


A) GABA;serotonin
B) serotonin;GABA
C) GABA;acetylcholine
D) acetylcholine;serotonin
E) serotonin;dopamine

F) D) and E)
G) A) and C)

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Benzodiazepines such as diazepam (Valium) act by increasing the inhibitory effects of the neurotransmitter:


A) acetylcholine.
B) norepinephrine.
C) dopamine.
D) gamma-aminobutyric acid (GABA) .
E) 5-hydroxytryptamine (serotonin) .

F) A) and B)
G) D) and E)

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Drugs used to relax the patient and promote sleep are classified as:


A) sedative-hypnotics.
B) antidepressants.
C) antipsychotics.
D) neuroleptics.
E) antidyskinetics.

F) B) and C)
G) A) and D)

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When certain sedative-hypnotics are suddenly discontinued,sleep disturbances may increase.This situation is commonly known as:


A) tardive dyskinesia.
B) anterograde amnesia.
C) rebound insomnia.
D) malignant hyperthermia.
E) none of the above

F) B) and E)
G) B) and D)

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C

Problems such as a "hang-over" effect and other residual symptoms that occur the morning after a person takes a sedative-hypnotic can often be resolved by:


A) lowering the dose of the sedative-hypnotic.
B) switching to a drug that has a shorter half-life.
C) switching to a newer agent (zolpidem,zalepon) ,which tends to have milder residual effects.
D) all of the above
E) none of the above

F) C) and D)
G) A) and E)

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D

Antidepressants such as paroxetine (Paxil) or venlafaxine (Effexor) can also be used to treat anxiety because:


A) they may be an effective substitute for people who cannot tolerate the side effects of traditional antianxiety drugs.
B) they may resolve certain cases of anxiety with less chance of addiction.
C) many patients with anxiety also have symptoms of depression
D) all of the above
E) none of the above

F) C) and D)
G) A) and B)

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