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Can a virus be killed?


A) Yes,destroying its genome kills it.
B) No,viruses are capable of self-assembly and cannot be permanently killed.
C) Yes,separating the genes from the capsid kills it.
D) No,viruses are nonliving and cannot die.

E) All of the above
F) B) and C)

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Virulent viruses multiply within infected cells and eventually


A) cause an alternation of generations in the host cell,releasing new viruses.
B) cause the transformation of the host cell,releasing new viruses.
C) cause lysis of the host cell,releasing new viruses.
D) cause the transduction of the host cell,releasing new viruses.
E) cause a transfer of material from the host cell,releasing new viruses.

F) B) and D)
G) A) and E)

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Nearly all viruses are constructed of


A) DNA with a protein wrapping,called a capsid.
B) RNA with a protein wrapping,called a capsid.
C) either DNA or RNA with a protein wrapping,called a capsid.
D) either DNA or RNA,however many do not have the capsid.

E) None of the above
F) A) and D)

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What kind of pathogen would retain its ability to cause infections after being treated with powerful proteolytic chemicals that would destroy all proteinaceous material?


A) A virus
B) A prion
C) A fungus
D) A bacterium
E) A viroid

F) B) and D)
G) A) and B)

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Nucleotide analogs are a class of drugs that are highly effective against many types of viruses.They work by halting the replication of viral genes.They are equally effective at stopping the spread of prion diseases.

A) True
B) False

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Vibrio cholerae lives in water and gets toxin genes from a virus by phage conversion.The toxin kills the intestinal epithelial cells in the human host,resulting in massive diarrhea.Untreated cholera has about a 50% mortality rate.How do the bacteria benefit?


A) Diarrhea helps the bacteria to spread from person to person.
B) Killing humans provides nutrients for the bacteria.
C) They don't -- humans are not the main host and their symptoms are maladaptive for the bacteria.
D) The bacteria reproduce faster in a dead human.

E) A) and B)
F) A) and D)

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All of the following are diseases caused by viruses except


A) strep throat.
B) AIDS.
C) polio.
D) small pox.
E) measles.

F) A) and E)
G) D) and E)

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________ infects the CD4+ T cells,which are required for normal immunity.

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Viruses are ________ -coated fragments of DNA or RNA.

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A doctor's office has run out of the latest flu vaccine,but many patients are asking for it.One of the nurses finds some vials from last year's batch in a refrigerator.Should they be used?


A) Yes,because the preservatives and refrigeration ensure that the vaccine is still fresh.
B) No,because each year the technology to make a good vaccine improves.
C) No,because each year the vaccine is made against different subtypes of the flu virus.
D) Maybe - the vaccine should be mixed in a test tube with the virus to see if it still inactivates it.

E) B) and D)
F) B) and C)

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Retroviruses are unique because they are a combination of RNA and DNA.

A) True
B) False

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Phages are viruses that can infect


A) humans.
B) plants.
C) insects.
D) farm animals.
E) bacteria.

F) C) and E)
G) D) and E)

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What is the name for parasitic viral DNA that has been integrated into the chromosome of its bacterial host?


A) prophage
B) prophase
C) viroid
D) virion
E) arbovirus

F) A) and B)
G) A) and C)

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Plasma from a sick mouse is filtered across a membrane that has a 200 nm pore size.If the filtrate is still infectious when injected into a healthy mouse,then the pathogen is most likely a(n) :


A) bacterium
B) archaean
C) fungus
D) virus
E) parasitic worm

F) A) and B)
G) A) and C)

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Once a prophage is present in a bacterial genome,viral genes are reproduced every time the bacterium multiplies.Expression of viral genes,however,is inhibited by a repressor protein.Cell stress can induce the formation of proteases that degrade the repressor.What will result?


A) The virus will enter the lysogenic cycle.
B) The bacterium will reject the viral genes.
C) The virus will enter the lytic cycle.
D) The bacterial genome will be denatured.

E) A) and C)
F) B) and D)

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Which class of drugs would be effective against HIV but not against most other pathogenic viruses?


A) Nucleotide analogs that halt replication.
B) Receptor antagonists that block viral entry.
C) Non-nucleoside reverse transcriptase inhibitors that block reverse transcription.
D) Translation inhibitors that stop assembly of viral proteins.

E) A) and B)
F) A) and C)

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An example of an "emerging virus" (a virus in a new host) with a lethality rate in excess of 50% is


A) influenza virus.
B) Ebola virus.
C) hepatitis B.
D) variola virus.
E) yellow fever.

F) B) and C)
G) C) and D)

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An experimental chemical has been shown to selectively cleave phosphodiester bonds.How would this affect a virus?


A) Fragment the genome
B) Digest the capsid
C) Dissociate the envelope
D) Alter the host binding site
E) Hydrolyze the protein coating

F) A) and E)
G) B) and E)

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The pneumonia caused by the influenza virus results from the accumulation of fluid and cell debris in the lungs.This occurs during the lysogenic life cycle of the virus.

A) True
B) False

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Which of the following is a virus with an icosahedral head,a capsid that contains primarily three proteins,a connecting neck with a collar and long whiskers,a long tail and a complex base plate?


A) influenza virus
B) measles virus
C) T4 bacteriophage
D) HIV
E) tuberculosis

F) B) and D)
G) A) and B)

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