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While conducting an experiment,you realize that a competitive inhibitor was interfering with your reaction.How could you overcome this problem?


A) Add a noncompetitive inhibitor to the reaction.
B) Add a cofactor to the reaction.
C) Increase the concentration of the correct substrate in the reaction.
D) Add an allosteric activator to the reaction.

E) All of the above
F) B) and C)

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In an enzyme-catalyzed reaction,the reactant is called the


A) coenzyme
B) catalyst
C) substrate
D) product

E) A) and B)
F) A) and C)

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A current problem in modern medicine is the development of drug resistance mutations.This occurs when a mutation arises in a disease-causing microbe making it resistant to a drug and thus rendering the drug useless in treating a specific disease.Many useful drugs are competitive inhibitors of specific enzymes,and the drug-resistance mutations prevent the binding of the drug.These types of mutations,in addition to preventing competitive inhibitor binding,can also sometimes reduce the activity of the enzyme.Why is that the case?


A) Binding to the competitive inhibitor is essential for the function of the enzyme
B) These mutations most likely affect an allosteric site on the enzyme
C) These mutations lower the activation energy of the reaction catalyzed by the enzyme
D) These mutations most likely change the shape of the active site of the enzyme

E) A) and D)
F) A) and B)

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Hexokinase is an enzyme that binds specifically to glucose and converts it into glucose 6-phosphate.The activity of hexokinase is suppressed by glucose 6-phosphate,which binds to hexokinase at a location that is distinct from the active site.This is an example of.


A) feedback inhibition.
B) competitive inhibition.
C) cofactor binding.
D) allosteric activation.

E) B) and C)
F) A) and D)

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The energy needed to destabilize existing chemical bonds and start a chemical reaction is called


A) activation energy
B) free energy
C) kinetic energy
D) potential energy

E) A) and D)
F) A) and C)

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If the ΔG of a reaction was -31.45 kJoules,you would know that:


A) the products have more free energy than the reactants.
B) the reaction requires an energy input of 31.45 kJoules to proceed.
C) the reaction most likely leads to development of a more ordered system.
D) the reaction is spontaneous.

E) C) and D)
F) A) and D)

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In a chemical reaction,glyceraldehyde-3-phosphate + NAD+ yields 1,3-bisphosphoglycerate + NADH.In this reaction,what happened to NAD+?


A) It was oxidized to form NADH
B) It was reduced to form NADH
C) It was activated to form NADH
D) it served as an enzyme to catalyze the reaction,and at the end of the reaction formed NADH

E) A) and B)
F) All of the above

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A drug binds to the active site of an enzyme.If it is bound to the active site of the enzyme,it prevents substrate binding.This drug would be considered a(n)


A) noncompetitive inhibitor.
B) allosteric inhibitor.
C) allosteric activator.
D) competitive inhibitor.

E) All of the above
F) A) and B)

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Enzyme 1 converts substrate A into product B.Is this an example of a metabolic pathway?


A) Yes.This is a metabolic pathway that includes feedback inhibition.
B) No.This only describes one chemical reaction.A metabolic pathway includes multiple chemical reactions.
C) Yes.This is a simple metabolic pathway.
D) No.A metabolic pathway must include an inhibitory step.

E) B) and D)
F) None of the above

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A new antibiotic has been developed.It acts as a noncompetitive inhibitor of an enzyme.How will this antibiotic affect delta G for the reaction that is catalyzed by the enzyme?


A) Delta G will increase
B) Delta G will decrease
C) Delta G will be unaffected

D) A) and B)
E) All of the above

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In the hypothetical biochemical pathway,P → Q + R → S → T,which step is likely to have evolved first?


A) P → Q
B) Q + R
C) R → S
D) S → T

E) B) and C)
F) A) and D)

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Under standard conditions,ATP can release for every molecule converted to ADP


A) less than 1 cal of energy.
B) 1 to 2 cal of energy.
C) 7) 3 Kcal of energy.
D) different amounts of energy depending on the cell.

E) A) and D)
F) A) and C)

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A particular chemical reaction is exergonic.What can you say about the relationship between the reactants and the products in this exergonic reaction?


A) The reactants have more free energy than the products
B) The reactants are likely more disordered and the products are likely more ordered
C) The reactants cannot spontaneously react to generate the products
D) The reactants likely have lower enthalpy than the products

E) None of the above
F) All of the above

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