Question 1

The sequencing method that cuts DNA segments into fragments, arranges those fragments based on overlapping nucleotide sequences, and then clones these fragments is called

Accepted Answer

A)  shotgun sequencing.
B)  clone-by-clone sequencing.
C)  RFLP sequencing.
D)  consensus sequencing.E) A) and B)
F) A) and C)

Question 2

Identical copies of genes that can be transcribed simultaneously are called

Accepted Answer

A)  segmental duplications.
B)  pseudogenes.
C)  tandem clusters.
D)  multigene families.E) None of the above
F) A) and C)

Question 3

A defining characteristic of draft sequences is that they have

Accepted Answer

A)  many gaps in regions of highly repetitive DNA.
B)  less than 1 error in 10,000 nucleotides.
C)  been found in various proteomes across the eukaryote life forms.
D)  been produced by alternative splicing.E) All of the above
F) C) and D)

Question 4

Groups of related, but distinctly different genes that appear to have arisen from a single ancestral gene are referred to as

Accepted Answer

A)  segmental duplications.
B)  pseudogenes.
C)  tandem clusters.
D)  multigene families.E) A) and B)
F) A) and C)

Question 5

Rice and its grain relatives, maize, barley, and wheat, diverged from a common ancestor 50 million years ago.However, the chromosomes of these plants demonstrate extensive conserved arrangements of segments.This phenomenon is called

Accepted Answer

A)  linkage disequilibrium.
B)  single nucleotide polymorphisms.
C)  contig.
D)  synteny.E) C) and D)
F) None of the above

Question 6

As a scientist working for an anti-bioterrorism task force, you are asked to evaluate some biological samples for the presence of Yersinia pestis, the organism that causes the plague.After confirming that the samples do contain Y.pestis, you instruct your team to begin sequencing the strain.Since the genome sequence of Y.pestis is already known, why would sequencing this strain be useful?

Accepted Answer

A)  To provide better data for the genome database
B)  To establish the course of infection, and determine whether the strain is altered by causing infection
C)  To help determine the source of the strain, and learn whether it has been genetically engineered
D)  To create a vaccine for this particular strainE) B) and D)
F) B) and C)

Question 7

Microarrays are created by robotically placing DNA on to a microscope slide and probing with

Accepted Answer

A)  RNA from the tissue of interest.
B)  another DNA from the tissue of interest.
C)  SNPs from the tissue of interest.
D)  STSs from the tissue of interest.E) A) and B)
F) A) and D)

Question 8

To avoid confusion and facilitate ease of data interpretation, researchers working on cloned DNA from the same species use

Accepted Answer

A)  restriction fragment length polymorphisms.
B)  shotgun sequencing.
C)  sequenced-tagged sites.
D)  clone by clone sequencing.E) B) and C)
F) A) and D)

Question 9

A human gene is composed of numerous fragments of protein-encoding information known as _______.

Accepted Answer

A)  DNA
B)  mRNA
C)  exons
D)  intronsE) A) and B)
F) B) and C)

Question 10

A pharmaceutical company is developing a new drug to treat a rare disease.They need to determine which of the cell's proteins can bind the drug.What tool can help them survey the proteome for drug interactions?

Accepted Answer

A)  ENCODE
B)  protein microarray
C)  using a monoclonal antibody
D)  SAGEE) B) and D)
F) B) and C)

Question 11

The ends of chromosomes are called ________.

Accepted Answer

A)  telomeres
B)  centromeres
C)  caps
D)  DNA terminiE) All of the above
F) C) and D)

Question 12

Conserved arrangements of segments of DNA in related genomes are referred to as

Accepted Answer

A)  synteny.
B)  homology.
C)  analogous DNA.
D)  a contig.E) B) and D)
F) All of the above

Question 13

You are studying a novel protein.To learn more about it, you performed a screen in yeast to identify proteins that could interact with it.From the screen you got a clone for a second gene.You had the clone sequenced, and you translated the gene sequence on your computer.What is the next logical step to learn more about the function of these two proteins?

Accepted Answer

A)  Run a BLAST search.
B)  Identify the intron/exon organization.
C)  Localize the gene to a specific chromosomal region.
D)  Search the human genome sequence for your clone.E) None of the above
F) A) and C)

Question 14

Mobile bits of DNA that can jump from one location on a chromosome to another location are called

Accepted Answer

A)  simple sequence repeats.
B)  transposons.
C)  exons.
D)  introns.E) None of the above
F) All of the above

Question 15

A transgene is best described as

Accepted Answer

A)  hard to destroy once inserted into a genome.
B)  hard to study because of its transposons.
C)  created by several of the DNA motifs.
D)  an inserted foreign gene.E) All of the above
F) None of the above

Question 16

You have been asked to construct a physical map of the baboon genome.What would be helpful in this task?

Accepted Answer

A)  chromosome maps and STSs
B)  BLAST and ENCODE data
C)  gene linkage data
D)  microarrays and SAGEE) C) and D)
F) B) and D)

Question 17

A large portion (45%)  of the human genome is composed of

Accepted Answer

A)  introns.
B)  exons.
C)  templates.
D)  transposons.E) None of the above
F) A) and B)

Exam 18: Genomics

A pharmaceutical company is developing a new drug to treat a rare disease.They need to determine which of the cell's proteins can bind the drug.What tool can help them survey the proteome for drug interactions?

Correct Answer
verified

A large portion (45%) of the human genome is composed of

Correct Answer
verified

A human gene is composed of numerous fragments of protein-encoding information known as _______.

Correct Answer
verified

Conserved arrangements of segments of DNA in related genomes are referred to as

Correct Answer
verified

Microarrays are created by robotically placing DNA on to a microscope slide and probing with

Correct Answer
verified

The ends of chromosomes are called ________.

Correct Answer
verified

You have been asked to construct a physical map of the baboon genome.What would be helpful in this task?

Correct Answer
verified

Rice and its grain relatives, maize, barley, and wheat, diverged from a common ancestor 50 million years ago.However, the chromosomes of these plants demonstrate extensive conserved arrangements of segments.This phenomenon is called

Correct Answer
verified

A defining characteristic of draft sequences is that they have

Correct Answer
verified

Groups of related, but distinctly different genes that appear to have arisen from a single ancestral gene are referred to as

Correct Answer
verified

Correct Answer
verified

The sequencing method that cuts DNA segments into fragments, arranges those fragments based on overlapping nucleotide sequences, and then clones these fragments is called

Correct Answer
verified

Correct Answer
verified

Mobile bits of DNA that can jump from one location on a chromosome to another location are called

Correct Answer
verified

A transgene is best described as

Correct Answer
verified

Identical copies of genes that can be transcribed simultaneously are called

Correct Answer
verified

To avoid confusion and facilitate ease of data interpretation, researchers working on cloned DNA from the same species use

Correct Answer
verified

Exam 18: Genomics

A pharmaceutical company is developing a new drug to treat a rare disease.They need to determine which of the cell's proteins can bind the drug.What tool can help them survey the proteome for drug interactions?

Correct AnswerverifiedShow Answer

A large portion (45%) of the human genome is composed of

Correct AnswerverifiedShow Answer

A human gene is composed of numerous fragments of protein-encoding information known as _______.

Correct AnswerverifiedShow Answer

Conserved arrangements of segments of DNA in related genomes are referred to as

Correct AnswerverifiedShow Answer

Microarrays are created by robotically placing DNA on to a microscope slide and probing with

Correct AnswerverifiedShow Answer

The ends of chromosomes are called ________.

Correct AnswerverifiedShow Answer

You have been asked to construct a physical map of the baboon genome.What would be helpful in this task?

Correct AnswerverifiedShow Answer

Rice and its grain relatives, maize, barley, and wheat, diverged from a common ancestor 50 million years ago.However, the chromosomes of these plants demonstrate extensive conserved arrangements of segments.This phenomenon is called

Correct AnswerverifiedShow Answer

A defining characteristic of draft sequences is that they have

Correct AnswerverifiedShow Answer

Groups of related, but distinctly different genes that appear to have arisen from a single ancestral gene are referred to as

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

The sequencing method that cuts DNA segments into fragments, arranges those fragments based on overlapping nucleotide sequences, and then clones these fragments is called

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Mobile bits of DNA that can jump from one location on a chromosome to another location are called

Correct AnswerverifiedShow Answer

A transgene is best described as

Correct AnswerverifiedShow Answer

Identical copies of genes that can be transcribed simultaneously are called

Correct AnswerverifiedShow Answer

To avoid confusion and facilitate ease of data interpretation, researchers working on cloned DNA from the same species use

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

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verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified