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List and describe two significant events in the history of genetics that occurred during the twentieth century.

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1. Discovery of the structure of DNA: In...

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Identify a TRUE statement from the following descriptions concerning genetics.


A) The theory of pangenesis states that all living organisms are composed of cells.
B) Bacteria and viruses are not useful in studying genes and inheritance because they are structurally and metabolically different from eukaryotic cells.
C) Charles Darwin accurately described the laws of inheritance in his landmark book, On the Origin of Species.
D) Many human traits, such as skin and hair color, are determined by more than a single gene.
E) Evolution can occur without genetic changes in the population.

F) C) and E)
G) B) and D)

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Many good ideas in science ultimately turn out to be incorrect and this has happened several times in the history of genetics. Why do you think a particular idea was widely accepted by scholars of that time? Include in your answer some evidence in favor of the idea, observations that seemed to support the idea, or other rationale for accepting the idea.

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One example of a widely accepted but ult...

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Which of the following species is considered a model genetic organism?


A) the plant Linaria vulgaris
B) the deer mouse Peromyscus maniculatus
C) the worm Caenorhabditis elegans
D) the frog Hyla chrysoscelis
E) the chimpanzee Pan troglodytes

F) C) and D)
G) C) and E)

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A measurable or observable trait or characteristic is called a:


A) phenotype.
B) genotype.
C) single-nucleotide polymorphism.
D) small interfering RNA.
E) gene bank.

F) B) and D)
G) C) and D)

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The three-dimensional structure of DNA was first deciphered based on the work of which of the following individuals? (Select all that apply.)


A) James Watson
B) Francis Crick
C) Maurice Wilkins
D) Thomas Hunt Morgan
E) Rosalind Franklin

F) A) and B)
G) B) and C)

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Permanent, heritable changes in genetic information (DNA) are called:


A) evolution.
B) defects.
C) SNP.
D) alleles.
E) mutations.

F) A) and D)
G) All of the above

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Identify a FALSE statement from the following descriptions of genetics.


A) Humans first applied genetics to the domestication of plants and animals between approximately 10,000 and 12,000 years ago.
B) Some viruses use RNA to carry their genetic information.
C) Albinism results from a mutation in the genes that control the synthesis and storage of melanin.
D) All human traits that display blending inheritance are affected by a single gene.
E) The process by which genetic information is copied and decoded is similar for all forms of life.

F) All of the above
G) C) and E)

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Which one of the following pairings between the subdiscipline of genetics and the phenomenon is INCORRECT?


A) evolution-population genetics
B) gene regulation-molecular genetics
C) allelic frequency alteration-population genetics
D) arrangement of genes on chromosome-transmission genetics
E) chemical nature of the gene-transmission genetics

F) C) and E)
G) B) and C)

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Albinism is rare in most human populations, occurring at a frequency of about 1 in 20,000 people. However, the trait occurs at a frequency of 1 in 200 in certain Hopi villages of Black Mesa in Arizona. Explain in terms of natural selection why albinism is so rare in most human populations.

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Albinism is a genetic condition characte...

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Within cells, genes are located on structures called:


A) genomes.
B) chromosomes.
C) phenotypes.
D) genotypes.
E) alleles.

F) A) and E)
G) None of the above

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The contribution of Gilbert and Sanger to modern genetics was to:


A) develop the PCR technique.
B) discover DNA in the nucleus of cells.
C) describe the structure of DNA.
D) show that genes were made of DNA.
E) develop a method for sequencing DNA.

F) C) and D)
G) A) and B)

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_____ is a change in allele frequency of a population over time.


A) Blending inheritance
B) Preformation
C) Genome
D) Evolution
E) Phenotype

F) None of the above
G) A) and E)

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Which of the following combines molecular biology and computer science?


A) single-nucleotide polymorphism
B) microRNAs
C) polymerase chain reaction
D) bioinformatics
E) eukaryotics

F) B) and D)
G) None of the above

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The contribution Charles Darwin made to biology was to:


A) demonstrate the connection between Mendel's principles of inheritance and evolution.
B) propose that evolution occurs by natural selection.
C) develop the theory of evolution, based on earlier theories of population genetics.
D) connect the fields of evolution and molecular genetics.
E) determine the first DNA sequence for a free-living organism.

F) None of the above
G) C) and E)

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Which of the following statements is FALSE concerning prokaryotic cells?


A) They lack a nuclear membrane.
B) They lack organelles such as chloroplasts.
C) They are less complex than eukaryotic cells.
D) They lack genetic information.
E) They lack a true nucleus.

F) All of the above
G) A) and E)

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In the late 1990s what important discovery in genetics was made?


A) The three-dimensional structure of DNA was described, which showed how DNA might be replicated.
B) The first recombinant DNA experiments were performed that started the biotechnology field.
C) DNA sequencing methods were first discovered.
D) Genes were found to be located on chromosomes.
E) Tiny RNAs were discovered that play important roles in the regulation of gene expression.

F) B) and D)
G) A) and B)

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The fruit fly Drosophila melanogaster is an important model system for studying inheritance in animals and genetic control of animal development, including humans. If researchers ultimately want to understand a biological process in humans, why might they want to study the process in fruit flies first? (Select all that apply.)


A) Fruit flies are relatively easy to genetically manipulate and to isolate mutations.
B) Fruit flies have short generation times and produce relatively large numbers of progeny.
C) Fruit flies have simpler genomes than do humans.
D) Fruit flies share all important physiological and developmental processes with humans.
E) Fruit flies are small and easy to raise.

F) A) and E)
G) A) and B)

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Which of the following pairs is a part of a single nucleotide?


A) nitrogenous base and sugar
B) sugar and amino acid
C) guanine and cytosinetwo nitrogenous bases
D) amino acid and nitrogenous base

E) A) and C)
F) All of the above

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In humans, single nucleotide differences among individuals, called single nucleotide polymorphisms (SNPs) , have been used to show:


A) how a mutation in a gene can lead to a particular trait.
B) how gene therapy can be used to treat various disorders.
C) the correlation of a set of genetic differences with a particular medical condition.
D) that the concept of the inheritance of acquired characteristics is not correct.
E) that genetic information can be transferred from DNA to RNA.

F) All of the above
G) A) and C)

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